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Patient resources

Feel informed. Feel ready.

Knowing what to expect makes screening easier to face. Clear answers about the tests, the procedure and what to do next.

2Compare the tests

Two approaches. Different capabilities.

Convenience matters. So does understanding what happens before a result, and after it.

Colonoscopy and Cologuard compared
What mattersColonoscopyCologuard / Cologuard Plus
How it worksA camera looks at the colon and rectum.A stool sample is checked for DNA and blood signals.
Removing polypsCan remove them during the exam.Cannot remove polyps.
Preparation & visitBowel preparation, usually sedation, and a ride home.You collect a sample at home. No bowel preparation or sedation for the stool test.
If something is foundRemoval or biopsy may be possible; further care depends on what is found.A positive result requires colonoscopy.
What to keep in mindCan miss growths. Risks include bleeding, perforation and sedation reactions.Can miss cancer and precancer; false positives occur. Repeat testing and follow-up matter.

General comparison, not a head-to-head cancer-outcome trial. Sources: NCI, FDA labeling, USPSTF.

Before you choose

Three questions for a more informed choice.

Bring these to your clinician when you compare the options.

  1. How well does each option find cancer, and advanced precancer?

    Ask about both. Advanced precancer means higher-risk growths that can become cancer, found before they do.

  2. Am I a good candidate for a high-quality colonoscopy?

    Discuss exam quality, preparation, the risks of the procedure, and how to arrange an exam in a timely way.

  3. What happens after a positive or negative result?

    Ask when to repeat testing, what follow-up is needed, and how symptoms or your history could change the plan.

3What it’s actually like

Common screening questions

A short answer first, then the details. Symptoms or a higher-risk history may change the right plan for you.

Do I need colon cancer screening if I have no symptoms?

That’s exactly when screening is meant to happen.

Precancerous polyps and early cancer usually cause no symptoms. Colonoscopy can find polyps and remove them in the same exam, before they have the chance to become cancer.

Your next step: If you’re due for screening, don’t wait for symptoms. If you already have rectal bleeding, lasting bowel changes or unexplained weight loss, contact your clinician for an evaluation, even after a negative stool test.

Sources: NCI: why screening matters · NIH: symptoms and colonoscopy

Do I need colon cancer screening if I have no family history?

No family history does not mean no risk.

Most colorectal cancers occur in people with no family history of it. A family history can mean starting earlier; not having one doesn’t mean skipping screening.

Your next step: Average-risk screening generally begins at 45. Go over your age, previous tests, health and family history with your clinician to find out whether you’re due.

Sources: ACS: family history and risk · Screening recommendations

How much time do I need for a colonoscopy?

Plan for preparation, the procedure and recovery.

Plan for bathroom access during the prep, and for time away from work on the procedure day if you’re sedated. You’ll need a ride home. Many people return to their usual activities the next day, but follow your team’s discharge restrictions.

Sources: AGA: planning and recovery · Screening intervals

What about my comfort and privacy?

Your next step: Tell the team what worries you: pain, embarrassment, loss of control, or a past experience. Ask how they will protect your privacy, what sedation to expect, and what accommodations are possible. You deserve that conversation before you consent.

Sources: AGA: what happens during the exam

Sources checked September 27, 2026 · U.S. coverage information; confirm your own plan’s terms.

Patient handouts

A clearer conversation. A page to take with you.

Printable education for patients and the clinicians who care for them.

Preview of the handout “Before it’s cancer.”

Before it’s cancer.

A concise guide to prevention, the Cologuard Plus precancer-detection finding, screening timing, and questions to discuss with your clinician.

Version 2 · October 2, 2026 · U.S. Letter

4See if you’re due, then arrange it

Plan your colonoscopy.

Three steps: make contact, confirm the details, get ready.

Have symptoms or a higher-risk history? Contact your clinician; your plan may differ. Colonoscopy First doesn’t book appointments or endorse individual providers.

Am I due? Arrange it