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Two numbers. Different questions.
Cancer detection and precancer detection answer different questions.
Cologuard Plus, one screening round, FDA analysis: 95.3% sensitivity for cancer, 43.3% for advanced precancer.
The evidence behind it
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95.3%: cancer sensitivity.
43.3%: advanced precancer sensitivity.
Cologuard Plus, one screening round, FDA BLUE-C primary effectiveness analysis. Colonoscopy can find and remove precancerous polyps during the same exam.
Single-round detection is not a measure of lifetime prevention. Colonoscopy can miss lesions and has risks. BLUE-C was funded by Exact Sciences.